The Coyote engine is 4.3 sec 0-60 the Boss is actually 4.5 or 4.7 both with 3.73. I've done both and I liked both. I know your not worried about fuel, but I liked the distance capable 3.73 and the kick of the 4.10. With a 4.10 you'll break traction more in rain and ice, and I believe the higher you go 4.10 4.56 the more stress you put on the other components.
I have a Shaft Master aluminum with Steel braided lines, FR 3.73 and a FR rear alum diff cover. Soon I will add a Yukon posi (stronger for drag, T2 better for track) the Traction Loc in it is just a bookmark, Alloy shafts in the diff, Spec (stage 1) clutch with Spec flywheel. Hope that bomb proofs it.
Every time someone breaks a component in their drive-line, it's usually a combo of strong motor and sticky slicks.