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5.0L (1979-1995) MustangTechnical discussions on 5.0 Liter Mustangs within. This does not include the 5.0 from the 2011 Mustang GT. That information is in the 2005-1011 section.
Your going to have to check piston to valve clearance with that cam. Your also going to have to get the spring seats machined on those heads to use that cam. Aftermarket springs for that kind of lift won't be able to be installed at the proper height without machining the seats.
back in the day i ran the motorsport x-cam with the factory sled rockers and at 542 lift they were fine. ptv clearance wasnt an issue either. they say the sleds are good to 550 lift so i was right on the edge.