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u will notice 2-4 miles per gallon depending on how aggressive you cam is meaning stage 1 or stage 2 and how much you have your foot in it. Just idling with cams will suck the gas but well worth it.
I recommend you go with stage IIs and if you are ever thinking of going F/I then go ahead now with a custom blower cam which will work fine n/a.
anything head performance wise will make your mpg's go down. how much i dont know but i think the thump and lope sounds of the cam will make it all worth it.