When I turn on my deck.. i hear a little bit of popping coming from the sub when the amp turns on, and then when i start driving and accelerating and slowing down theres a little high pitch noise coming from my speakers and the sound of the noise varies on how much throttle im giving it... Theres no interference when Im at a stop but it does also come on when the engine is one, when its on ACC its pretty clear.

The popping noise is similar to the post Headunit swap popping noise but i dont have a factory amp.. obviously
I Ran my 4 gauge on the drivers side and the signal wires down the passenger side... The picture below shows the 4 gauge wire coming from the spar tire, but thats only extra slack witch i coiled and ziptied and is now under my rear seats (drivers side).
Where im thinking the noise is coming from is the distributor block because its in the middle of the two amps and theres wires galore..
http://img181.imageshack.us/img181/7294/p1011092en7.jpg

 

sounds like you might be getting engine/alternator noise....might be a grounding problem.... make sure your radio is grounded, and both amps are grounded. you could even ground the actual housings of the amps and the radio. Best ground is the ground to the battery, its a PIA but its the best. I would try that first....if that doesnt work, might need to filter the signal...