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Shoehorned in looks like the correct word. If your really thinking of this and have the money, I'd look into racing front coil-over clip. Likea Chris Alston Chassic. Get rid of the strut towers and K-member. Now you'd open up the whole area for headers and tuning plus any size or year motor. Good luck.
Big difference between a Boss 429 and you're average 429. But either swap is a waste of time and money. Just strap a blower or turbo to your 4.6 and you'll have more power then a nicely built 429 and quite a bit lighter too.