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I have 3:73's and it doesnt afftect gas milage too much, and if you plan on getting a supercharger in the future get 3:73's and if not then go with 4:10's
Get at least the 4.10`s and be done (FRPP`s) Even if you get a S/C you will be fine. I know guys running 4.10`s that have a S/C and they arent complaining. Dont worry about the gas. Its not that bad.
Gas mileage wont differ that much. with 3.73 probly 0-1 mpg difference on the highway. 4:10 1-2 mpg difference highway. city will depend on how you drive, you have a possiblity of getting a little better mpg than with stock gears, but that depends on driving habbits
I was offered a truck to borrow because my relatives figured i would be getting about 12 mpg with my gears on the highway.