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I rememeber these two guys who had gears....one with 3.73 and the other with 4.10s.....they said the difference was about 2 to3 mpg difference(highway) between the 3.73s and 4.10s...but it also depends on how you drive....if you have 4.10s and drive like a dog off its lesh, then yeah, your gona lose way more gas compared to stock or 3.73s.....i say go 4.10 for n/a engines and 3.73 for f/i....but its all about driver preference, there is no right or wrong until you decide what you want out of the car