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4.10's wouldn't be too much unless you're blown or boosted I'd think. Originally I ordered 4.10's but they ended up getting back-ordered and I had the choice to switch to 3.73's or wait. Now I'm wishing I'd have just waited. At 70mph I'm sitting at around 2200rpms, and I've gotten as high as 31mpg highway. I believe the difference between 3.73's and 4.10's is something like 200rpm at 60mph or something like that. I know it wouldn't be terrible. As far as 1st gear goes, unless you don't know what partial throttle is, your 1st gear should still be completely usable.