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I had a RoushCharger that I installed on my 2006 F-150 with 5.4 3v
very very fun. I know lots of guys running 550 crank HP (about 400-450 RWHP...lots of drivetrain loss in the F-150) with tune + 8 PSI + exhaust...I know it's comparing Apples to Oranges...but the Roush can put out some power easily.
Overall, the Whipple will make more HP...but it costs more money up front. A RoushCharger is a great cheap way to have alot of fun for a daily driver.
I like twins...the twins will rock your world. Whipple would be the way to go.