Can i turn my O2's off altho i am running a custom tune? if i can only get it turned off by the tuner will it hurt to drive the car?

Oh and i have a Diablo.

 

I assume you mean the rear O2's after the cats. I've never used a Diablo, but the other handheld tuners I've seen all can disable the rear O2's. I'm sure your Diablo can as well. The rear O2's are simply for emissions and will not hurt your car at all to run with them enabled or disabled. You'll want to disable them though to get rid of the CEL light.

 

agreed...i'm sct, with rear's disabled, passed inspection with flying colors